BRCA Panel (BRCA1, BRCA2)

Casandra

Casandra Test Code QD64443Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 91863

BRCA Panel (BRCA1, BRCA2)

Also known as: Genetic Breast Cancer, Hereditary Breast Cancer, Hereditary Ovarian Cancer, BRACA

Clinical Use

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Use

Used to identify individuals with increased risk for hereditary breast and ovarian cancer syndrome, particularly in individuals with Ashkenazi Jewish ancestry and/or personal or family history of breast, ovarian, pancreatic, or metastatic or high‑grade prostate cancers. Genetic counseling and informed consent are strongly recommended before testing. Individuals with a positive result have a pathogenic or likely pathogenic variant in BRCA1 and/or BRCA2 and are at increased cancer risk; a negative result does not rule out risk. Panels do not detect all causes of hereditary predisposition, and variant classification may change over time. (Source: Quest Diagnostics FAQ)

Special Instructions

Sample reports and variant analysis details are available via QuestHereditaryCancer.com. A genomic science specialist is available by calling Quest Genomics Client Services at 1.866.GENE.INFO. Insurance coverage is verified upon receipt of a completed order; if patient responsibility exceeds $100, healthcare provider and/or patient are notified before test initiation.

Limitations

Test is limited to BRCA1 and BRCA2 genes and does not assess other genes associated with hereditary breast cancer. Not all regions of these genes may be analyzed. Rare or novel variants may have unclear effects, and false positives or negatives may occur. Results should be interpreted in context of clinical findings, history, and other data; genetic counseling is recommended. (Sources: Quest FAQs)

Test Details