Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA

Casandra

Casandra Test Code AR15292Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0092566CPT Code 83516

Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA

Also known as: BP180 230G

Clinical Use

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Use

This test is used to monitor disease in patients diagnosed with pemphigoid and elevated IgG BP180 and/or BP230 antibody levels. It is not recommended for initial diagnosis or to discriminate among immunobullous diseases. For monitoring disease progression and intermittent evaluation, the test can be used alongside other panels, such as the Basement Membrane Zone Antibody Panel or Immunobullous Disease Antibody Panel. The presence of these antibodies is associated with bullous pemphigoid and may assist in determining disease activity and treatment response.

Special Instructions

The test is approved for use in New York. It requires serum collected in a plain red or serum separator tube, and specimens should be shipped to the laboratory as soon as possible. For specimens less than 0.5 mL, contact the Immunodermatology Laboratory.

Limitations

Normal results do not exclude a diagnosis of pemphigoid or other immunobullous diseases. Up to 7 percent of individuals without pemphigoid may show increased levels of IgG BP180 and/or BP230 antibodies. The test does not detect all possible antibodies present in immunobullous diseases, and results should be interpreted in conjunction with clinical findings.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

BP180

Protein

IgG BP180 antibody level • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

BP230

Protein

IgG BP230 antibody level • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

57911-0

Result Turnaround Time

3-9 days

Specimen

Serum

Volume

2 mL

Minimum Volume

0.5 mL

Container

Plain red or serum separator tube (SST)

Collection Instructions

Transfer serum to an ARUP standard transport tube. Ship to the laboratory as soon as possible.

Storage Instructions

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received, store and ship refrigerated. If greater than 14 days, store and ship frozen.