c-kit, CD117
Use
CD117 (c-kit) is a proto-oncogene activated in gastrointestinal stromal tumors (GISTs). This IHC stain highlights mast cells (normal and abnormal) in the assessment of mast cell neoplasms, and is used to confirm GIST. Staining is also observed in mast cells and myeloid stem cells.
Special Instructions
Not provided.
Limitations
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected. Turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.
Methodology
Immunoassay (IHC)
Biomarkers
CD117
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED)
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours |