Use

This advanced DNA‑based next‑generation sequencing (NGS) assay analyzes leukocytes from whole blood or bone marrow aspirate for frameshift mutations in exon 9 of the CALR gene, which are associated with myeloproliferative neoplasms (MPN), particularly essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations are mutually exclusive with JAK2 and MPL mutations and confer different prognostic implications compared to JAK2‑mutated cases.