Carbamazepine, Total (Change effective as of 10/21/24: Refer to 2011763 in the October Hotline)

Casandra

Casandra Test Code AR33464Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0090260CPT Code 80156

Carbamazepine, Total (Change effective as of 10/21/24: Refer to 2011763 in the October Hotline)

Also known as: TEG

Clinical Use

Order Test

Use

Optimize drug therapy and monitor patient adherence. The test measures total carbamazepine in serum (trough) at steady-state concentration and supports therapeutic drug monitoring in light of drug‑drug interactions, protein binding displacement, and metabolism factors. It also includes interpretive insight concerning risk of Stevens‑Johnson syndrome or toxic epidermal necrolysis associated with HLA‑B*15:02 genotype. Combination with pharmacogenetic testing may benefit at-risk patients. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/0090260))

Special Instructions

Not provided.

Limitations

Cross‑reactivity with metabolites may cause differences in carbamazepine values among analytical methods. Pharmacogenetic risk (HLA‑B*15:02) requires additional testing for hypersensitivity risk. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/0090260))

Test Details

New York Approved

Methodology

Immunoassay

Biomarkers

Carbamazepine

Analyte

Carbamazepine • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

3432-2

Result Turnaround Time

Not provided.

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Plain red tube

Collection Instructions

Allow specimen to clot completely at room temperature; separate serum from cells as soon as possible or within 2 hours of collection; transfer 1 mL serum to ARUP Standard Transport Tube.