Casandra
Casandra Test Code NG60912Version 1 (DRAFT)
Performing Lab
CBFB (16q22)
Clinical Use
Order TestUse
This assay detects structural rearrangements—specifically inversion of chromosome 16 [inv(16)] and translocation t(16;16)—in the CBFB gene, which are associated with acute myeloid leukemia (AML), including the M4E variant (acute myelomonocytic leukemia / AML‑M4E), aiding diagnosis and classification.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown chromosome
ChromosomeStructural Rearrangement(s)
Other • Categorical (e.g., Positive / Negative / Indeterminate)
CBFB
Other • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Bone Marrow
Volume
1‑2 mL
Minimum Volume
Not provided
Container
Sodium Heparin Tube (EDTA acceptable)
Collection Instructions
Bone Marrow Aspirate: 1‑2 mL in sodium heparin tube; EDTA tube acceptable
Storage Instructions
Use cold pack for transport, not in direct contact with specimen
Causes for Rejection
Include date/time for NYS; exclude biopsy needles, blades, foreign objects