CD4, technical only
Use
CD4 is expressed on helper/inducer T-cells and at a lower level on monocytes. Most cases of cutaneous T-cell lymphoma, including mycosis fungoides, express the CD4 antigen. Further, HTLV-1 associated adult T-cell leukemia/lymphoma and sites of inflammation are generally CD4 positive. Technical component only. Pathologist read not included.
Special Instructions
Not provided.
Limitations
This test is for the technical component only; it does not include a pathologist's interpretation. Immunohistochemistry results might vary based on tissue fixation and processing methods. Specimens fixed in non-standard fixatives may be rejected, leading to potential delays.
Methodology
Immunoassay (IHC)
Biomarkers
CD4
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Storage Instructions
Ambient storage at 15°C to 25°C. Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours |