CD8 T-Cell Immune Competence Panel, Global, Whole Blood

Casandra

Casandra Test Code MC14769Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID GLICPCPT Codes 86355, 86356, 86357, 86359, 86360

CD8 T-Cell Immune Competence Panel, Global, Whole Blood

Clinical Use

Use

This test is used for determining over immunosuppression within the CD8 T-cell compartment, particularly in transplant recipients and patients with autoimmune disorders receiving immunosuppressants. It assesses CD8 T-cell function by measuring intracellular IFN-gamma expression and surface CD107a/CD107b expression, providing insight into immune competence, especially after induction immunosuppression or for monitoring maintenance therapy to ensure adequate T-cell function without over-immunosuppression. This helps in balancing the risk of graft rejection and infectious complications.

Special Instructions

This test requires multiple whole blood specimens; if only one type is received, testing may be limited. Specimens must be shipped in an Ambient Shipping Box following the instructions provided, and shipping should occur within 24 hours of collection. Specimens arriving after 4 p.m. on Friday, weekends, or holidays may be canceled. Collect specimens at the same time of day for serial monitoring.

Limitations

The assay is specific to CD8 T cells and does not provide information on overall T-cell competence. Impairment due to over-immunosuppression may result in decreased IFN-gamma production and increased infection risk. The assay may not correlate directly with drug levels due to individual pharmacokinetic variations, making functional assessment critical.

Test Details