Cholinesterase, Plasma
Also known as: Pseudocholinesterase
Use
Approximately 1 in every 2,500 individuals has an inherited defect or deficiency of pseudocholinesterase (the enzyme that metabolizes succinylcholine, an anesthetic agent). These individuals may experience prolonged apnea after normal doses of succinylcholine due to their reduced enzyme activity. Low plasma cholinesterase levels may also be observed in individuals exposed to organophosphorus insecticides or patients with hepatic dysfunction.
Special Instructions
Not provided.
Limitations
Results may be depressed in patients using oral contraceptives. Hepatic disease may cause up to a 70% reduction in enzyme levels. Plasma cholinesterase may be slightly elevated in obese or diabetic patients.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Pseudocholinesterase (plasma cholinesterase)
Analyte
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
EDTA (lavender-top) tube; plasma aliquot tube
Collection Instructions
Draw an EDTA (lavender-top) tube of whole blood. Spin tube to separate plasma. Pour plasma into plastic aliquot tube. Refrigerate until shipping. Ship refrigerated. Do not send packed cells or whole blood.
Storage Instructions
Refrigerated until shipping
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 21 days |
| Refrigerated | 21 days |
| Frozen | 30 days |
Other tests from different labs that may be relevant