Chromosomal Microarray, POC, ClariSure® Oligo‑SNP
Also known as: POC, Oligo-SNP Microarray, Microarray, Oligo-SNP, Products of Conception
Use
The ClariSure® Oligo‑SNP Postnatal chromosomal microarray (CMA) enables detection of copy number variants and regions of homozygosity across the genome, valuable in identifying genetic etiologies of congenital anomalies, developmental delay, intellectual disability, and autism spectrum disorders, especially in cases lacking successful chromosome culture.
Special Instructions
Product of conception (POC) tissue that fails to grow in culture can still be analyzed using this microarray approach. Use of fresh tissue and submission of clinical/pregnancy history is recommended. Contact Quest Genomics Client Services at 866‑GENE‑INFO for guidance or to add additional testing.
Limitations
This assay cannot detect mosaicism below ~20% level, balanced rearrangements (e.g., Robertsonian or reciprocal translocations, inversions), single‑gene disorders (e.g., Marfan syndrome, fragile X syndrome), or deletions/duplications below the assay’s resolution. It may not distinguish between a normal female fetus and maternal cell contamination.
Methodology
Microarray
Biomarkers
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
Not provided
Minimum Volume
5 x 5 mm preferred; 2 x 3 mm minimum
Container
sterile container in Hanks', Ringer’s solution, or culture medium with antibiotics
Collection Instructions
Tissue collected in sterile container in Hanks', Ringer’s solution, or culture medium with antibiotics
Storage Instructions
Do not freeze; transport fresh under recommended conditions
Causes for Rejection
Formalin‑fixed specimens, frozen samples, necrotic tissue, or obviously contaminated specimens cannot be used
Other tests from different labs that may be relevant