Chronic Lymphocytic Leukemia (CLL) Panel
Use
The FISH panel test is designed to detect the most common genetic abnormalities observed in chronic lymphocytic leukemia. It specifically targets important loci such as MYB (6q23), ATM (11q22.3), and TP53 (17p13) which are known to have clinical implications in the diagnosis and prognosis of CLL.
Special Instructions
Ensure specimens are collected using EDTA whenever possible, as it is the preferred anticoagulant. The bone marrow is typically the sample of choice for CLL testing. Efforts will be made to process and report samples even if they are received more than 72 hours after collection.
Limitations
The test is designed to detect only the most common genetic deletions associated with CLL. It does not identify other potential genetic alterations or provide a comprehensive genomic profile of the cancer. Delays in specimen transport or improper handling may affect the accuracy of results.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
Store between 2°C and 25°C
Causes for Rejection
Clotted specimen; Specimens exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |