Clomipramine and Metabolite, Serum or Plasma

Casandra

Casandra Test Code AR04839Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0099336CPT Codes 0480, 80335

Clomipramine and Metabolite, Serum or Plasma

Also known as: CLOMIP

Clinical Use

Order Test

Use

This test is used to optimize dosing and monitor patient adherence to clomipramine therapy, especially concerning its antidepressant characteristics. The therapeutic range helps in assessing the efficacy of the drug in alleviating depressive symptoms, although a therapeutic range for treating obsessive-compulsive disorder is not well established. Monitoring clomipramine levels is crucial given the potential toxic effects, such as anticholinergic effects, CNS depression, cardiac abnormalities, seizures, and hypotension, which can occur at higher concentrations.

Special Instructions

Specimen collection should be done as a predose (trough) draw at steady-state concentration. It is important to separate serum or plasma from cells within two hours of collection and transfer to an ARUP standard transport tube for accurate analysis. Test is approved for use in New York.

Limitations

Toxic concentrations of clomipramine can result in significant clinical effects, making the monitoring of levels critical. The therapeutic ranges pertain to depression treatment, and there is no well-established range for obsessive-compulsive disorder, which may limit its interpretive use in this context.

Test Details

New York Approved