Clonazepam

Casandra

Casandra Test Code AR21538Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0090055CPT Codes 0480, 80346

Also known as: CLON

Clinical Use

Order Test

Use

This test is used to optimize dosing and monitor patient adherence for individuals prescribed Clonazepam. Monitoring the drug level is essential because it helps in assessing the therapeutic range, which is 20-70 ng/mL. It also assists in identifying toxic levels, which are greater than 80 ng/mL. Clonazepam is typically prescribed in doses ranging from 1-8 mg/d in adults. The test provides vital information on patient compliance and assists in adjusting dosages to minimize adverse effects such as drowsiness, headache, fatigue, and ataxia.

Special Instructions

Not provided.

Limitations

This test has specific limitations, such as requirements for storage and specimen type to ensure accuracy. Specimens collected in gel separator tubes or light blue (sodium citrate) are unacceptable, as are hemolyzed samples. It is also important to note that the test has not been cleared or approved by the FDA but is developed under CLIA certification for clinical purposes. Repeated freeze/thaw cycles should be avoided, and stability varies with storage conditions: ambient (1 week), refrigerated (2 weeks), and frozen (3 years).

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Clonazepam

Analyte

Concentration

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

3494-2 - clonazePAM SerPl-mCnc

Result Turnaround Time

1-7 days

Specimen

Serum

Volume

2 mL

Minimum Volume

1 mL

Container

ARUP standard transport tube

Collection Instructions

Collect using gray (potassium oxalate/sodium fluoride) tube. Also acceptable are plain red, green (sodium heparin), lavender (K2 or K3EDTA), or pink (K2EDTA) tubes.