Collagen Type VII Antibody, IgG by ELISA

Casandra

Casandra Test Code AR44762Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2010905CPT Code 83516

Collagen Type VII Antibody, IgG by ELISA

Also known as: COLLAG 7

Clinical Use

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Use

The test is used to monitor disease in patients diagnosed with epidermolysis bullosa acquisita (EBA) or bullous lupus erythematosus who have increased IgG type VII collagen antibody levels. It is not intended as an initial diagnostic tool but rather for monitoring disease progression or changes. Initial diagnosis and discrimination among various immunobullous diseases are better served by using broader antibody panels such as the Immunobullous Disease Antibody Panel or Basement Membrane Zone Antibody Panel.

Special Instructions

For initial diagnosis and differentiation among various immunobullous diseases, broader antibody panels like the Immunobullous Disease Antibody Panel or Basement Membrane Zone Antibody Panel are preferred. Specimens should be shipped to the laboratory as soon as possible and stored refrigerated unless shipping promptly.

Limitations

The test is not suitable for initial diagnosis of immunobullous diseases as it may not detect antibodies to basement membrane zone antigens other than type VII collagen epitopes displayed in this ELISA. It also does not rule out other disorders with similar symptoms, such as anti-laminin-332 pemphigoid or anti-p200 pemphigoid, especially if associated with other conditions.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

Collagen Type VII

Protein

IgG Type VII Collagen Antibody • Other • Categorical (e.g., Positive / Negative / Indeterminate)

Result Turnaround Time

3-9 days

Specimen

Serum

Volume

2 mL

Minimum Volume

0.5 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Transfer 2 mL serum to an ARUP Standard Transport Tube.

Storage Instructions

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.