Copper, Random Urine

Casandra

Casandra Test Code AR06843Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2011480CPT Code 82525

Also known as: U COP RAND

Clinical Use

Order Test

Use

This test is useful in assessing copper overload, particularly in individuals with conditions like Wilson disease, cholestatic liver disease, and proteinuria, where elevated urine copper levels can be indicative. While random urine samples may contain diagnostic information, a 24-hour urine collection is recommended for a consistent indicator of urine copper levels.

Special Instructions

Patients should discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications if possible. Avoid sample collection from patients who have recently received iodinated or gadolinium-based contrast media for at least 72 hours post-exposure, or for at least 14 days from patients with impaired kidney function.

Limitations

High concentrations of iodine or gadolinium can interfere with elemental testing, leading to potentially inaccurate results. Additionally, elevated results may be due to contamination from collection containers not certified as trace element-free. If contamination is suspected, confirmation with a second specimen in a certified trace element-free container is recommended.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Copper, Urine - per volume

Analyte

Copper, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Copper, Urine - ratio to CRT

Analyte

Copper, Urine - ratio to CRT • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Creatinine, Urine - per volume

Analyte

Creatinine, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

30920-3
35674-1
13829-7

Result Turnaround Time

1-5 days

Specimen

Urine

Volume

8 mL

Minimum Volume

1 mL

Container

ARUP Trace Element-Free Transport Tubes

Collection Instructions

Transfer an aliquot from a well-mixed random urine collection into the specified transport tubes.

Patient Preparation

Discontinue use of nutritional supplements, vitamins, minerals, and nonessential medications. Avoid collection within 72 hours of administration of contrast media.

Storage Instructions

Refrigerated transport recommended. Room temperature or frozen conditions are also acceptable.

Causes for Rejection

Samples collected within 72 hours of contrast media administration, acid-preserved urine, use of non-specified containers, or contamination with blood or fecal material.