Copper, Urine

Casandra

Casandra Test Code AR49608Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0020461CPT Code 82525

Also known as: COPPER U

Clinical Use

Order Test

Use

This test is useful in assessing trace element overload conditions. It is particularly relevant in the context of Wilson Disease and can help evaluate cholestatic liver disease, proteinuria, and other conditions that may lead to elevated urine copper. A 24-hour urine collection provides a consistent indicator of copper excretion, which is essential for accurate diagnosis and monitoring of these conditions.

Special Instructions

Patients should discontinue nutritional supplements, vitamins, and nonessential medications as they may introduce interfering substances. Avoid collecting specimens from patients exposed to iodinated or gadolinium-based contrast media for at least 72 hours, and for at least 14 days post-exposure if the patient has impaired kidney function. Collect and store specimens in ARUP Trace Element-Free Transport Tubes to minimize contamination risk.

Limitations

Elevated results may be caused by contamination from non-certified collection containers or skin contaminants during collection. Elevated urine copper may also be due to certain medications or medical conditions unrelated to trace element overload. This test has not been cleared or approved by the FDA. Interpret results with caution, considering potential contaminations and inconsistencies from non-24-hour urine collections.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Copper

Analyte

Copper, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Copper, Urine - per 24h • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Copper, Urine - ratio to CRT • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Creatinine

Analyte

Creatinine, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Creatinine, Urine - per 24h • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

30920-3
5633-3
35674-1
2162-6
13829-7
19153-6
30211-7

Result Codes

30920-3
5633-3
35674-1
2162-6
13829-7
19153-6
30211-7

Result Turnaround Time

1-5 days

Specimen

Urine

Volume

8 mL aliquot

Minimum Volume

1 mL

Container

Plastic container, ARUP Trace Element-Free Transport Tubes (ARUP supply #43116)

Collection Instructions

Collect a 24-hour urine and refrigerate during collection. Random urine also acceptable. Transfer an 8 mL aliquot to ARUP Trace Element-Free Transport Tubes. Record total volume and collection time interval on transport tube and test request form.

Patient Preparation

Discontinue nutritional supplements, vitamins, and nonessential medications. Avoid specimen collection from patients exposed to iodinated or gadolinium-based contrast media for 72 hours. For patients with impaired kidney function, avoid specimen collection for at least 14 days post-contrast media exposure.

Storage Instructions

Refrigerated. Room temperature or frozen is also acceptable.

Causes for Rejection

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media, acid preserved urine, specimens transported in non-specified containers, specimens contaminated with blood or fecal material.