Cryptococcus Antigen Titer, Lateral Flow Assay, Serum
Use
This test is useful for monitoring Cryptococcus antigen titers in serum and aiding in the diagnosis of cryptococcosis. Cryptococcosis is an invasive fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii, which are typically acquired via the pulmonary route. High-risk populations include those with immunosuppressive conditions such as AIDS. The presence of cryptococcal antigen in serum is indicative of cryptococcosis; however, titers should not be used as a test of cure or to guide treatment decisions.
Special Instructions
The test should not be used as a screening procedure for the general population and is intended for individuals with clinical evidence suggesting the diagnosis of cryptococcal disease. Consistent assay usage is advised for monitoring, as titers acquired by different methods are not interchangeable.
Limitations
Cryptococcus antigen titers acquired by the lateral flow assay may be higher than those acquired by other assays and are non-interchangeable. Positive results should be contextualized with other clinical findings and caution must be taken with hemolyzed serum samples that may lead to false negatives. Rare, extremely high concentrations of cryptococcal antigen may show weak test lines or yield negative results. This assay has not been evaluated for cross-reactivity with trichosporonosis.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 9818-6
- 9818-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |