Cyclosporine, Peak, Blood
Use
This test is useful for monitoring whole blood peak cyclosporine concentration during therapy, especially for individuals taking cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers. It aids in adjusting doses to optimize immunosuppression while minimizing toxicity and evaluating patient compliance.
Special Instructions
Not provided.
Limitations
No definitive therapeutic or toxic ranges have been established for peak testing. Therapeutic drug monitoring is essential due to cyclelosporine's narrow therapeutic range and interactions with other drugs leading to increased neuro- and nephrotoxicity. Results of this assay, measured by liquid chromatography with tandem mass spectrometry, are approximately 30% less than those from immunoassay.
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
Cyclosporine
Analyte
LOINC Codes
- 53834-8 - cycloSPORINE Peak Bld-mCnc
- 53834-8 - cycloSPORINE Peak Bld-mCnc
- 29742-4 - Date Last Dose
- 29637-6 - Tme Last Dose
- 4207-7 - cycloSPORINE Dose
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA)
Collection Instructions
Do not centrifuge. Send whole blood specimen in the original tube. Do not aliquot.
Causes for Rejection
Clotted specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
