Dengue Virus Antibody, IgG and IgM, Serum
Use
Dengue virus (DV) is a globally distributed flavivirus with 4 distinct serotypes. It is primarily transmitted by the Aedes aegypti mosquito, posing a significant public health threat. The presence of IgG antibodies is consistent with past exposure, while IgM antibodies indicate an acute-phase infection. Detection of these antibodies is crucial for diagnosing dengue infections, which can have substantial health implications, particularly in tropical and subtropical regions.
Special Instructions
Positive test results should be interpreted with consideration of clinical evaluation and exposure history. False-positives may occur with other flavivirus infections. Specimens collected too soon after exposure may not detect IgM antibodies, whereby repeat testing might be necessary.
Limitations
False-positive results may occur, especially with other flavivirus infections like Zika or West Nile virus. Interpretation should consider recent blood product transfusions, immunosuppressive states, and the potential cross-reactivity of IgG antibodies with other flaviviruses.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 87546-8
- 29661-6
- 29663-2
- 69048-7
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |