Diabetes Risk Index (DRI)
Use
The Diabetes Risk Index (DRI) is intended for use in adult subjects for the quantitative determination of a risk score in serum or plasma. The DRI score (1-100) may be used as an aid in stratifying the risk of developing type 2 diabetes in individuals with normo-glycemia or prediabetes.
Special Instructions
The test requires specific specimen handling, such as the use of a lavender-top or plain red-top tube. Fasting for 10 to 12 hours is recommended before the test. Specimens should be shipped on frozen cool packs. It is essential not to use serum or plasma in gel-barrier collection tubes other than the NMR LipoTube for this test.
Limitations
The test exhibits some limitations, including an average 8-point lower measurement from plasma specimens compared to serum specimens. Additionally, the freeze/thaw cycle results in a 10% increase in the DRI upon the first cycle without further changes on successive cycles. Caution should be taken with the type of collection tubes used, as serum or plasma drawn in gel-barrier collection tubes other than the NMR LipoTube are not acceptable.
Methodology
Other
Biomarkers
LOINC Codes
- 94560-0
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender-top (EDTA-no gel) tube (preferred) or plain red-top tube or NMR LipoTube (black-and-yellow-top tube); green-top (sodium heparin) plasma tube also acceptable
Collection Instructions
Collect specimen in a lavender-top (EDTA-no gel) tube. For plain red-top tube, allow to clot for 45 minutes, centrifuge, and transfer to a transport tube for storage at 2°C to 8°C until shipped. For NMR LipoTube, allow to clot for 30 minutes, centrifuge immediately, and store at 2°C to 8°C until shipped. Do not open NMR LipoTube. Separate plasma immediately after collection and transfer to a plastic transport tube for shipment.
Patient Preparation
Fasting for 10 to 12 hours is recommended.
Storage Instructions
Refrigerate prior to shipment and ship on frozen cool packs.
Causes for Rejection
Unspun LipoTube or unseparated plain red-top or EDTA tube; serum or plasma specimen drawn in a gel-barrier collection tube other than the NMR LipoTube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Lipotube Serum: 1 day; Plain Serum: 1 day; EDTA Plasma: 8 hours; Sodium Heparin Plasma: 8 hours |
| Refrigerated | Lipotube Serum: 8 days; Plain Serum: 8 days; EDTA Plasma: 8 days; Sodium Heparin Plasma: 7 days |
| Frozen | All tubes: 15 days |
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