Diphtheria Antibody, IgG

Casandra

Casandra Test Code AR57384Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0050210CPT Code 86317

Diphtheria Antibody, IgG

Also known as: DIP

Clinical Use

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Use

The Diphtheria Antibody test is used to evaluate a patient's ability to produce antibodies to a pure protein vaccine after vaccination. This aids in ruling out antibody deficiency by assessing immune response to diphtheria vaccination. It is particularly useful in patients with suspected immunodeficiency or inadequate vaccine response. Responder status is determined based on antibody concentrations in post-vaccination specimens compared to pre-vaccination levels, providing insights into the quality of the vaccine response by classifying patients as non-responders, weak responders, or good responders.

Special Instructions

Pre-vaccination and post-vaccination specimens should be collected, with the post-vaccination sample drawn 30 days after immunization. Ensure specimens are clearly marked as 'Pre-Vaccine' or 'Post-Vaccine'. If shipped separately, the 'Post' specimen must be received within 60 days of the 'Pre' specimen.

Limitations

This test has not been cleared or approved by the US Food and Drug Administration (FDA). It is performed in a CLIA certified laboratory for clinical purposes but may not be suitable for regulatory purposes. Results interpretation should consider that high pre-vaccination antibody levels (> 1.0 IU/mL) can complicate response assessment based solely on ratios, and a post-vaccination concentration above 2.5 IU/mL in such cases is usually deemed adequate.

Test Details

New York Approved