Diphtheria & Tetanus Antibodies, IgG
Also known as: D/T
Use
This test evaluates the patient's ability to produce antibodies in response to diphtheria and tetanus protein vaccines, to identify potential antibody deficiencies. It is useful post-vaccination to determine protective immunity levels and can distinguish between non-responders and responders based on specific IgG concentration thresholds.
Special Instructions
Both 'pre' and 'post' vaccination specimens are required for testing. Ensure 'post' samples are drawn 30 days post-immunization and clearly marked. If shipping separately, 'post' samples must arrive within 60 days of the 'pre' samples.
Limitations
This test's accuracy in measuring the response to diphtheria and tetanus vaccines may be affected by the initial pre-vaccination antibody level. If pre-concentration is high, usual interpretive criteria may be less applicable, making response assessment challenging. It is not FDA approved, but performed in a CLIA certified environment for clinical purposes.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 13227-4
- 53935-3
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.15 mL
Container
Serum separator tube
Collection Instructions
"Pre" and "post" vaccination specimens should be submitted for testing. "Post" specimen should be drawn 30 days after immunization.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma or other body fluids.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
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