DOG-1
Use
DOG-1 was originally discovered in gastrointestinal stromal tumors (GIST) where it's predominantly on the plasma membrane. Because DOG-1 is rarely found in other soft tissue tumors, this marker is useful in the identification of GISTs, including platelet-derived growth factor receptor alpha mutants that fail to express KIT antigen.
Special Instructions
Not provided.
Limitations
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected. Stated turnaround times are subject to change based on biopharma protocol requirements, with final TATs specified in the biopharma study contract.
Methodology
Immunoassay (IHC)
Biomarkers
DOG-1
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE Block
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | Indefinite |