Casandra
Casandra Test Code NG90821Version 1 (DRAFT)
Performing Lab
DPC4
Also known as: SMAD4
Clinical Use
Order TestUse
The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) is located at 18q21.3. It is frequently mutated and deleted in pancreatic carcinomas (~55%) and less frequently in colon carcinomas (20–22%). Loss of expression is specific for pancreatic malignancy (in‑situ or invasive) versus benign process, making this immunohistochemical assessment especially helpful in biopsies.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
DPC4
ProteinExpression
Expression • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred or one unbaked, unstained slide for H&E (required) plus two to three positively charged unstained slides (cut at 4‑5 microns)