Dystonia and Parkinsonism Panel
Use
This panel evaluates individuals with combined features of dystonia and parkinsonism, which may be genetic or acquired in origin. It is used to aid diagnosis in patients presenting with movement disorder phenotypes, where both dystonia (characterized by patterned or twisting movements and postures) and parkinsonism (manifesting as resting tremor, muscle rigidity, bradykinesia, and postural instability) are observed. The panel supports differential diagnostic work-up and potential therapeutic guidance based on identification of responsible genetic causes.
Special Instructions
Refer to GeneDx’s neurology test requisition form for this panel (Test Menu T402) which includes sequencing and deletion/duplication analysis of 103 genes. GeneDx reserves right to upgrade ordered panel to current version listed on website. At-home cheek swab or blood accepted per standard GeneDx practices.
Limitations
Panel content, gene list, and technical limitations are subject to change; always consult gene list on GeneDx website or Test Requisition Form. Some causes of dystonia and parkinsonism may not be detectable by sequencing or CNV analysis, resulting in non-diagnostic outcomes. Negative results do not rule out genetic etiology due to undiscovered or non‐covered regions. Analytical limitations may include regions of low sequence coverage or structural complexity.
Methodology
NGS
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
Other tests from different labs that may be relevant