EGFR Gene, Targeted Mutation Analysis, 51 Mutation Panel, Tumor

Casandra

Casandra Test Code MC27636Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID EGFRSCPT Codes 81235, 88381

EGFR Gene, Targeted Mutation Analysis, 51 Mutation Panel, Tumor

Clinical Use

Use

This test is useful for identifying non-small cell lung cancers that may respond to epidermal growth factor receptor-targeted therapies. By analyzing the mutation status of the EGFR gene, it aids in selecting patients who might benefit from EGFR-targeted treatment. Molecular genetic profiling, as performed in this test, is crucial for identifying actionable mutations and minimizing treatment costs and associated risks.

Special Instructions

A pathology report must accompany the specimen for testing to be performed. When this test is ordered, slide review will always be performed, at an additional charge. Glass coverslips for cytology slides are preferred; plastic coverslips are acceptable but result in longer turnaround times. Cytology slides will not be returned; an image of the slides will be stored per regulatory requirements.

Limitations

A negative (wildtype) result does not rule out the presence of mutations that may be present but below the detection limits of this assay (approximately 10%). It also does not exclude the presence of other activating mutations in the EGFR gene. Not all patients with detected activating EGFR mutations will respond to EGFR-targeted therapies. Rare genetic alterations, such as polymorphisms, could result in false-negative or false-positive results.

Test Details

New York Approved