Eosinophilia FISH Panel
Use
The Eosinophilia FISH Panel is utilized to detect the most common genetic abnormalities associated with eosinophilia by analyzing hematologic specimens. It specifically includes tests for FIP1L1::PDGFRA (4q12) gene fusion, PDGFRB (5q32) rearrangement, and FGFR1 (8p11.2) rearrangement. These abnormalities are important for diagnosing conditions linked with eosinophilia and can assist in guiding further clinical management.
Special Instructions
Not provided.
Limitations
The test requires intact DNA for accurate FISH analysis; therefore, clotted specimens, those exposed to extreme temperatures, or with insufficient cell quantity may be rejected. The analysis is limited to detecting specific rearrangements and fusions included in the panel; rare or novel genetic abnormalities may not be identified.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
FGFR1 (8p11.2)
OtherFIP1L1-PDGFRA fusion
FusionPDGFRB (5q32)
Other
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |