Ewing Sarcoma, 22q12 (EWSR1) Rearrangement, FISH, Tissue
Use
Detection of EWSR1 rearrangements irrespective of the EWSR1 fusion partner gene. It supports the diagnosis of various neoplasms including Ewing sarcoma, extraskeletal myxoid chondrosarcoma, desmoplastic small round cell tumor, clear cell sarcoma, and myxoid liposarcoma when used in conjunction with pathologic assessment. The presence of EWSR1 rearrangement signifies a possible fusion with a partner gene, which is significant for the diagnosis.
Special Instructions
Not provided.
Limitations
This test is not FDA approved and should be used as an adjunct to existing clinical and pathologic information. Non-formalin fixed specimens and paraffin-embedded tissues that have been decalcified may not be successful for FISH analysis. A lack of FISH results may occur if no FISH signals are observed post-hybridization. Reflex testing with additional probes may occur at an extra charge.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 93806-8 - EWSR1 gene Rear Tiss FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Alternative fixation methods may be acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |