Factor XIII

Casandra

Casandra Test Code LC27214Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 086330CPT Code 85291

Also known as: Factor XIII, Qualitative, Fibrin Stabilizing Factor

Clinical Use

Order Test

Use

This is a screening assay and will detect homozygous deficiency of factor XIII.

Special Instructions

If the patient's hematocrit exceeds 55%, the citrate volume in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions. Avoid warfarin therapy for two weeks and heparin therapy for two days prior to the test. Ensure proper blood-to-anticoagulant ratio by filling evacuated collection tubes completely and mixing immediately by gentle inversion.

Limitations

This is a screening assay only and will show abnormal results when factor XIII levels are less than 1% to 2%. It will not provide quantitative levels of FXIII activity. For a quantitative functional analysis of FXIII, further testing with a different method is recommended. The test is limited to severe deficiencies and may not detect moderate or mild deficiencies. Interpreting results requires considering potential interference from conditions such as disseminated intravascular coagulation or liver disease.

Test Details

Methodology

Other

Biomarkers

Factor XIII

Protein

Other • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

3241-7

Result Codes

3241-7

Result Turnaround Time

3-4 days

Specimen

Plasma

Volume

1 mL

Minimum Volume

Not provided

Container

Blue-top (sodium citrate) tube

Collection Instructions

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio. Mix immediately by gentle inversion at least six times. If using a winged collection set, a discard tube should be drawn first to prevent under-filling.

Patient Preparation

Avoid warfarin (Coumadin®) therapy for two weeks and heparin therapy for two days prior to the test. Do not draw from an arm with a heparin lock or heparinized catheter.