Ganglioside (GM1) Antibodies, IgG and IgM

Casandra

Casandra Test Code AR40997Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0050591CPT Code 83516

Ganglioside (GM1) Antibodies, IgG and IgM

Also known as: GM1 PAN

Clinical Use

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Use

Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 antibodies may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Special Instructions

The test is useful when assessing for primarily motor neuron disease and motor neuropathies. It is performed on Tuesdays, Thursdays, and Saturdays, and results are reported within 1-7 days. The test should be used in conjunction with other clinical parameters to confirm disease.

Limitations

The test by itself is not diagnostic and should not be used as the sole basis for diagnosis. Elevated antibodies can also be found in normal individuals and those with diverse connective tissue diseases. The interpretation of the results should be considered in the context of other clinical observations and diagnostic measurements.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

2 components

GM1 IgG Component • ELISAGM1 IgM Component • ELISA

LOINC Codes

Order Codes

51703-7
51729-2

Result Codes

51729-2
51703-7

Result Turnaround Time

1-7 days

Specimen

Serum

Volume

0.3 mL

Minimum Volume

0.1 mL

Container

ARUP standard transport tube

Collection Instructions

Collect serum separator tube. Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.3 mL serum to an ARUP standard transport tube.