Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
Use
This test is useful for investigating unexplained weight loss, early satiety, anorexia, nausea, vomiting, constipation, or diarrhea in patients with a past or family history of cancer or autoimmunity. It helps in directing a focused search for cancer and is also used to investigate gastrointestinal symptoms appearing post-cancer therapy, aiding in differentiating autoimmune gastrointestinal dysmotility from chemotherapy effects. Moreover, it detects early evidence of cancer recurrence in patients with a rising titer of autoantibodies.
Special Instructions
Not provided.
Limitations
Negative results do not exclude autoimmune gastrointestinal dysmotility or cancer. Results may be affected if the specimen is collected post-treatment with intravenous immunoglobulin (IVIg), likely causing false positives.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 97557-3 - AGID Ab pnl Ser
- 33615-6 - Hu1 Ab Ser Ql
- 72504-4 - CV2 Ab SerPl Ql IF
- 94694-7 - nAChR Ab Ser IA-sCnc
- 84925-7 - PCA-2 Ab Ser Ql IF
- 69048-7 - Immunologist review
- 48767-8 - Annotation comment Imp
- 94287-0 - LGI1 IgG Ser Ql CBA IFA
- 94285-4 - CASPR2 IgG Ser Ql CBA IFA
- 94676-4 - DPPX IgG Ser Ql CBA IFA
- 101907-4 - AP3B2 IgG Spec Ql
Result Turnaround Time
8-12 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
2 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
For optimal antibody detection, specimen collection is recommended before starting immunosuppressant medication or IVIg treatment.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |