Gynecologic Pap Test (Image-guided), Liquid-based Preparation and Chlamydia/Gonococcus, NAA With Reflex to Human Papillomavirus (HPV) (Aptima®) When ASC-U With Reflex to HPV Genotypes 16 and 18,45
Use
Diagnose primary or metastatic neoplasm. This test aids in the diagnosis of sexually transmitted HPV infection and in the triage of patients with an ASCUS Pap test result. Detect Chlamydia trachomatis and Neisseria gonorrhoeae. High-risk HPV test is used for types 16,18,31,33,35,39,45, 51,52,56,58,59,66, and 68, without differentiation of the individual type. Positive high risk HPV test results reflex the sample for genotyping of types 16 and 18/45.
Special Instructions
Not provided.
Limitations
The test may produce false negatives due to suboptimal sampling, excessive use of lubricants, or insufficient cell population from certain regions. The use of the specimen for multiple tests may limit the availability of material for Pap reprocessing or HPV testing. Testing for Chlamydia and Gonococcus requires special processing, and thus cannot be added after submission.
Methodology
Other
Biomarkers
LOINC Codes
- 47527-7 - Cytology Cvx/Vag Doc Thin Prep
- 47528-5 - Cytology Cvx/Vag Doc Cyto
- 19764-0 - Stat of Adq Cvx/Vag Cyto-Imp
- 59420-0 - HPV I/H Risk 4 DNA Cvx Ql Probe+sig amp
- 77399-4 - HPV16 DNA Cvx Ql NAA+probe
- 77400-0 - HPV18 DNA Cvx Ql NAA+probe
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
ThinPrep® vial
Minimum Volume
Not provided
Container
ThinPrep® vial
Collection Instructions
Broom technique: Rotate the brush five times in the cervical os, rinse in PreservCyt® solution, and ensure proper release of material. Brush/spatula technique: Rotate brush in cervical canal, rinse in PreservCyt® solution. For Chlamydia and Gonococcus: Use Aptima® swab kit, ensuring correct steps for swab use and transport.
Patient Preparation
Avoid douches 48 to 72 hours prior, and avoid specimen collection during or shortly after menstruation.
Storage Instructions
Maintain at room temperature, process within 21 days for Pap.
Causes for Rejection
Improper collection, insufficient specimen, labeling issues, specimen leakage, submission on male patients, expired vials, frozen specimens, etc.