Use

The test is critical for evaluating lymphocytoses of undetermined etiology and identifying B- and T-cell lymphoproliferative disorders involving blood and bone marrow. It aids in distinguishing acute lymphoblastic leukemia from acute myeloid leukemia (AML) and allows for the immunologic subtyping of acute leukemias. Additionally, the test is used for distinguishing reactive lymphocytes, lymphoid hyperplasia from malignant lymphoma, and between malignant lymphoma and acute leukemia. It is also useful for the phenotypic subclassification of B- and T-cell chronic lymphoproliferative disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and hairy cell leukemia. Recognizing AML with minimal morphologic or cytochemical evidence of differentiation is another application, as well as recognizing monoclonal plasma cells. Notably, the test is not intended for the detection of minimal residual disease below 5% blasts.