Hemolytic Anemia Evaluation, Blood
Use
This evaluation is used for the assessment of lifelong or inherited hemolytic anemias, including red blood cell membrane disorders, unstable or abnormal hemoglobin variants, and red blood cell enzyme disorders. It provides a comprehensive evaluation to identify hereditary causes of increased red blood cell destruction and includes tests for membrane disorders like hereditary spherocytosis and pyropoikilocytosis, hemoglobinopathies, and enzyme defects.
Special Instructions
Preliminary screening tests like complete blood cell count with peripheral smear and direct Coombs test should be negative before ordering this evaluation. The evaluation requires specific specimen handling, including a shipping control to prevent false-positive results due to preanalytical artifacts.
Limitations
This test is not suitable for acquired causes of hemolysis such as autoimmune hemolytic anemia or other immune-based causes. It is of limited use in patients with recent transfusions and should be scheduled as far from a recent transfusion as possible. Specimens must be handled identically to the control to prevent compromised results due to handling or transport conditions.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 98903-8
- 2902-5
- 59466-3
- 98906-1
- 4639-1
- 34964-7
- 23915-2
- 23918-6
- 23920-2
- 23921-0
- 40431-9
- 20572-4
- 32682-7
- 4552-6
- 24469-9
- 78748-1
- 44051-1
- 2383-8
- 18771-6
- 44054-5
- 32552-2
- 44053-7
- 72664-6
- 49216-5
- 44050-3
- 32546-4
Result Turnaround Time
3-25 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
8 mL (2 EDTA tubes) + 12 mL (2 ACD tubes)
Minimum Volume
3 mL EDTA, 5 mL ACD
Container
Lavender top (EDTA) and Yellow top (ACD)
Collection Instructions
Collect and label patient specimens, refrigerate immediately after collection, and send in original tubes. Do not aliquot.
Storage Instructions
Refrigerate (or place on cold gel pack/small amount of wet ice) immediately after collection.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 72 hours |