HER-2 Immunohistochemistry (IHC), Gastric With Reflex to FISH if 2+ by IHC
Also known as: HER-2/neu Oncoprotein, Paraffin Block
Use
Evaluation of tumor tissue. Specimens demonstrating 2+ (moderate) staining for the HER-2/neu protein are evaluated for gene amplification status by FISH. In such cases, FISH provides a better indication of potential response to therapy.
Special Instructions
Direct any questions regarding this test to oncology customer service at 800-345-4363.
Limitations
Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results. ASCO/CAP 2013 guidelines recommend fixation time between 6 and 72 hours for breast tissue; however, special ASCO/CAP guidelines have not been established for gastric cancer samples.
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 18474-7
- 77202-0
- 72486-4
Result Turnaround Time
4-5 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Paraffin block transport pouch or slide mailer
Collection Instructions
FFPE tissue, preserved in 10% neutral buffered formalin, fixed for 18 to 24 hours.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Tumor other than gastric tumor
Other tests from different labs that may be relevant