Hereditary Cancer Single Site(s)
Also known as: BRCA, Familial mutation, Known familial mutation
Use
The Hereditary Cancer Single Site(s) test is used to identify the presence or absence of a known familial variant (known familial mutation, KFM) previously identified in a family member. It can additionally serve confirmatory purposes for research results, tumor profiling findings, direct-to-consumer testing, or raw data analysis. Official test results from the family member (or the individual) are required for laboratory review. This test is an option when a familial mutation has already been identified and is confined to any of the genes included in the Comprehensive Hereditary Cancer Panel (66 genes) ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq216?utm_source=openai)).
Special Instructions
Official test results of the family member, or of the individual if confirmatory testing, must be available for laboratory review. For ordering information or questions about a specific case, contact Quest Genomics Client Services at 1.866.GENE.INFO (1.866.436.3463) ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq216?utm_source=openai)).
Limitations
This test is limited to detection of the known familial variant only (KFM) and does not analyze any other gene regions beyond that variant. It cannot detect all causes of hereditary predisposition to cancer. Additional genetic testing may be appropriate depending on personal/family history. Results should be interpreted within the context of clinical findings, family history, and other laboratory data. Rare false-positive or false-negative results may occur. Clinical genetic counseling and comprehensive evaluation is recommended ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq216?utm_source=openai)).
Methodology
NGS
Biomarkers
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Not provided.
Other tests from different labs that may be relevant