Herpes Simplex Virus (HSV) Type 1- and Type 2-Specific Antibodies, IgG, Serum

Casandra

Casandra Test Code MC36212Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID HSVGCPT Codes 86695, 86696

Herpes Simplex Virus (HSV) Type 1- and Type 2-Specific Antibodies, IgG, Serum

Clinical Use

Use

This test is useful for determining whether a patient has been previously exposed to herpes simplex virus (HSV) types 1 and 2. It assists in distinguishing between infections caused by HSV types 1 and 2, especially in patients with subclinical or unrecognized HSV infection. However, it should not be used to diagnose active or recent infection. The presence of IgG-class antibodies to HSV types 1 or 2 indicates previous exposure, but does not necessarily indicate that HSV is the causative agent of an acute illness.

Special Instructions

Centrifuge and aliquot serum into a plastic vial. If not ordering electronically, complete and send the Infectious Disease Serology Test Request form with the specimen.

Limitations

Detection of IgG-class antibodies to HSV should not be used routinely to diagnose active infections, as serum specimens collected too early in the infection course may not have detectable levels of HSV IgG. False positives are possible, and the presence of IgG-class antibodies does not differentiate between remote infection or acute disease. Genital and nongenital infections can't be distinguished through HSV serology. Results' predictive value depends on disease prevalence and pretest HSV likelihood. Repeat testing or alternative methods might be required in some cases, especially when the infection likelihood is low.

Test Details

FDA Approved