Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF

Casandra

Casandra Test Code AR15392Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0050359CPT Code 86696

Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF

Also known as: HERPIICSF

Clinical Use

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Use

The test detects the presence of IgG antibodies specific to Herpes Simplex Virus Type 2 glycoprotein G in cerebrospinal fluid (CSF). Detection of these antibodies can indicate a current or past HSV infection. It is useful in assessing central nervous system infection due to HSV; however, it should be interpreted with caution due to potential contamination and transfer issues. A fourfold or greater rise in CSF antibodies to herpes, tested at least 4 weeks apart, is seen in a significant portion of patients with herpes encephalitis, but specificity based on a single testing is not established.

Special Instructions

This is not a standalone test. Molecular testing is preferred for herpes diagnostics, specifically using PCR for HSV-1/HSV-2 subtyping (test 2010095). If testing is performed for New York state, a Non-Permitted Laboratory Request Form must be submitted to NYDOH.

Limitations

The test cannot establish the presence of HSV Type 2 in the early stages of infection as antibodies may not be detectable. The test's specificity based on a single CSF test is not established. Detection in CSF could be due to blood contamination or serum antibody transfer across the blood-brain barrier. PCR remains the primary diagnostic tool for herpes encephalitis.

Test Details