Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF
Also known as: HERPIICSF
Use
The test detects the presence of IgG antibodies specific to Herpes Simplex Virus Type 2 glycoprotein G in cerebrospinal fluid (CSF). Detection of these antibodies can indicate a current or past HSV infection. It is useful in assessing central nervous system infection due to HSV; however, it should be interpreted with caution due to potential contamination and transfer issues. A fourfold or greater rise in CSF antibodies to herpes, tested at least 4 weeks apart, is seen in a significant portion of patients with herpes encephalitis, but specificity based on a single testing is not established.
Special Instructions
Not provided.
Limitations
The test cannot establish the presence of HSV Type 2 in the early stages of infection as antibodies may not be detectable. The test's specificity based on a single CSF test is not established. Detection in CSF could be due to blood contamination or serum antibody transfer across the blood-brain barrier. PCR remains the primary diagnostic tool for herpes encephalitis.
Methodology
Immunoassay (ELISA)
Biomarkers
HSV Type 2 Glycoprotein G
Protein
LOINC Codes
- 48401-4 - HSV2 gG IgG CSF-aCnc
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. Indicate source on test request form.
Storage Instructions
Refrigerated. Unacceptable if contaminated, heat-inactivated, or hemolyzed.
Causes for Rejection
Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
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