HLA-C Genotype
Also known as: HLA C
Use
The HLA-C Genotype test is employed in immunization or vaccination trials and aids in the clinical diagnosis of diseases that are strongly associated with the HLA-C locus. The test identifies specific HLA alleles that may be implicated in disease predisposition, providing valuable information for the management and treatment of conditions related to HLA-C.
Special Instructions
This test should be ordered for single antigen HLA-C identification. Specify the antigens to be tested. The test is performed by the Histocompatibility & Immunogenetics Laboratory at the University of Utah Health.
Limitations
This test alone does not establish a definitive diagnosis, as the presence of a disease-associated HLA combination is not sufficient for diagnosis. If fewer than two alleles are reported for a locus, the patient is likely homozygous. Diagnostic errors can occur due to mutations at primer or probe sites. The test is insufficient for comprehensive HLA evaluations required in clinical hematopoietic stem cell transplantation. For such purposes, a comprehensive HLA Class I and II panel by Next Generation Sequencing is recommended. Additionally, specific alleles may not be determined precisely, and only the most likely allele assignment will be provided with possible alternatives.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 42663-5
Result Turnaround Time
5-8 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B)
Storage Instructions
Refrigerated
Causes for Rejection
Specimens collected in green (sodium or lithium heparin) tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 1 week |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant