Human Papillomavirus (HPV) Genotype 16 and 18 by PCR, Head and Neck
Also known as: HN HPV PCR
Use
This test is used to detect human papillomavirus (HPV) genotype 16 and 18 in patients previously diagnosed with invasive head and neck squamous cell carcinoma. HPV 16 and 18 are significant because they are associated with head and neck cancers. The presence of these genotypes can provide important insights into the oncogenic potential of the viral infection in these cases, which helps in understanding the infectious etiology component of the cancer.
Special Instructions
Not provided.
Limitations
Negative results do not exclude the presence of other high-risk HPV types. The test's sensitivity can be influenced by factors such as specimen collection methods, the stage of infection, and the presence of interfering substances. It has not been cleared or approved by the FDA but is performed in a CLIA-certified laboratory and intended for clinical purposes. Its performance has been characterized by ARUP, despite the lack of FDA approval.
Methodology
PCR-based (PCR)
Biomarkers
HPV Genotype 16
MicroorganismHPV Genotype 18
Microorganism
LOINC Codes
- 31208-2
- 57723-9
- 77399-4
- 61373-7
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
4 slides
Container
Tissue block or 5 unstained 4-5 micron slides
Storage Instructions
Ship in cooled container during summer months.
Causes for Rejection
FFPE specimens without tumor tissue, specimens fixed in formalin substitutes, alternative fixatives or heavy metal fixatives, and decalcified specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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