IgE Antibody (Anti‑IgE IgG)
Also known as: Chronic Urticaria
Use
Autoimmune chronic urticaria is characterized by autoantibodies—either IgG to the high‑affinity IgE receptor (FcεRIα) or to IgE itself—which trigger mast cell and basophil degranulation. Functional anti‑IgE autoantibodies are identified in approximately 5–10% of patients, and IgG to the receptor in 30–40%. This assay quantifies anti‑IgE autoantibodies to aid in diagnosis and management of autoimmune chronic urticaria.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Immunoassay
Biomarkers
IgE Antibody (Anti‑IgE IgG)
Protein
Result Turnaround Time
3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
red‑top tube (no gel)
Collection Instructions
Serum should be separated from the cells as soon as possible after visible clot formation (usually 15‑30 minutes after collection)
Patient Preparation
Overnight fasting is preferred
Causes for Rejection
Gross or moderate hemolysis • Grossly lipemic • Heavy visible particulate matter • Grossly icteric
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 28 days |
Other tests from different labs that may be relevant