IGH::FGFR3; t(4;14)
Use
This FISH test is performed on hematologic specimens to detect the IGH::FGFR3 gene fusion. This fusion is associated with t(4;14) and may be observed in conditions like multiple myeloma, monoclonal gammopathy, and plasma cell leukemia. The detection of this fusion assists in the diagnosis and management of these hematologic malignancies.
Special Instructions
All efforts will be made to process samples received more than 72 hours post-collection. Bone marrow is the preferred sample for most hematologic malignancies. Use a refrigerated gel pack for shipping to protect from extreme temperatures; do not freeze the specimen.
Limitations
The test is based on FISH methodology and is limited to detecting the specific IGH::FGFR3 gene fusion associated with t(4;14). Specimens that are clotted, exposed to extreme temperatures, contain anticoagulants toxic to cells, or have an insufficient number of cells may be rejected.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |