Inflammatory Bowel Disease Serology Panel, Serum
Use
This test is used for distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations. It is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine. The presence of antineutrophil cytoplasmic antibodies in the absence of IgA and IgG anti-Saccharomyces cerevisiae antibodies is consistent with the diagnosis of ulcerative colitis; the presence of IgA and IgG ASCA in the absence of ANCA is consistent with Crohn disease.
Special Instructions
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Test Request (T728) with the specimen. Serum gel is the preferred collection tube, but a red top is acceptable.
Limitations
Results from this test should not be exclusively relied upon to establish the diagnosis of ulcerative colitis or Crohn disease or to distinguish between these two diseases. Some patients with CD have detectable antineutrophil cytoplasmic antibodies, and some patients with UC have detectable IgA and/or IgG anti-Saccharomyces cerevisiae antibodies. Some patients with UC or CD do not have detectable ANCA, IgA ASCA, or IgG ASCA. ANCA results may be reported as indeterminate if interfering antinuclear antibodies (ANA) are present.
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 87551-8
- 17355-9
- 49308-0
- 47320-7
- 47321-5
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.8 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Heat-treated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |