Isavuconazole (CRESEMBA) LC-MS/MS
Use
Isavuconazole is an antifungal agent used for the treatment of invasive aspergillosis and mucormycosis in patients. It is important to monitor isavuconazole levels to ensure therapeutic efficacy and avoid toxicity. The therapeutic range for isavuconazole has not been firmly established, making monitoring an integral part in therapy optimization. This test aims to provide healthcare providers with quantitative data to aid in the dosing and management of isavuconazole therapy.
Special Instructions
Ensure the serum sample is collected in a red top tube and aliquoted promptly into a plastic vial to avoid degradation. It is crucial to freeze the sample before sending it to ensure stability during transport.
Limitations
The assay measures isavuconazole with a range of 0.1-10 mcg/mL but lacks an established therapeutic range, making interpretation dependent on additional clinical factors. Hemolyzed or lipemic samples may be rejected, affecting the ability to perform the test. Additionally, the assay may not detect all metabolites or isomers, which could impact the comprehensive evaluation of isavuconazole concentrations.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot 1 mL of serum into a plastic vial. Send frozen.
Causes for Rejection
Gross hemolysis and gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 30 days |