Islet 1 Immunostain, Technical Component Only
Use
Islet 1 is a homeobox-gene-related transcription factor involved in the development of the endocrine pancreas. Islet 1 is expressed in endocrine pancreas, subsets of neurons of the adrenal medulla, and dorsal root ganglion cell layers in the retina, the pineal gland, and some areas of the brain. Islet 1 is a useful marker as it is positive in the majority of pancreatic endocrine tumors. This test is useful for the identification of endocrine tumors.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. Interpretation should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist. Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary among published literature and are antigen dependent. The charge of glass slides can be affected by environmental factors and may alter slide staining.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Islet 1
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block; or 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient |