Kappa Lambda Dual Stain by Immunohistochemistry
Also known as: KLDual IHC
Use
This test is used for the detection and differentiation of kappa and lambda light chains in tissue samples. These light chains are part of the immunoglobulins produced by B-cell lineages and their differential expression can indicate various hematologic conditions, such as B-cell lymphomas, plasma cell neoplasms, and related disorders. The staining helps pathologists in diagnosing and differentiating these conditions, providing critical information for appropriate treatment planning.
Special Instructions
Not provided.
Limitations
This test has not been cleared or approved by the US Food and Drug Administration. It is performed in a CLIA certified laboratory for clinical purposes. The test may not provide the necessary specificity or sensitivity in some cases due to potential cross-reactivity or suboptimal staining of some tissue types. False negatives may occur in poorly fixed tissue or if tissue samples are not representative of the lesion being investigated.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Kappa
ProteinLambda
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue block or slides in a Tissue Transport Kit
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen; cells must be prepared into a cellblock.
Storage Instructions
Protect paraffin block and/or slides from excessive heat. Ship in cooled container during summer months.
Causes for Rejection
Specimens submitted with nonrepresentative tissue type or depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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