Kappa/Lambda Light Chain Panel by In Situ Hybridization Stain Only

Casandra

Casandra Test Code AR72706Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3003525CPT Codes 88368, 88369

Kappa/Lambda Light Chain Panel by In Situ Hybridization Stain Only

Also known as: SO KLP ISH

Clinical Use

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Use

The test is used to quantify kappa and lambda light chains in paraffin tissue. These light chains are part of the immunoglobulin molecules, and their measurement can help in the assessment of monoclonal gammopathies and other related disorders. By evaluating the kappa/lambda ratios, clinicians can distinguish between polyclonal and monoclonal proliferation, which is useful in diagnosing and monitoring conditions such as multiple myeloma and other lymphoproliferative disorders.

Special Instructions

Not provided.

Limitations

The test does not include interpretation of the kappa/lambda light chains quantification results. It's vital to pair results with clinical findings and other diagnostic tests for comprehensive evaluation. The test is not FDA approved but is performed in a CLIA-certified laboratory. Specimens that are non-representative or depleted are unacceptable for analysis. Frozen specimens are also unacceptable, as stability is only guaranteed under ambient or refrigerated conditions.

Test Details

New York Approved

Methodology

Chromosomal / Cytogenetics (ISH)

Biomarkers

Kappa

Protein

ISH

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

Lambda

Protein

ISH

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

94736-6 - Tissue block ID Spec

Result Turnaround Time

2-5 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

4 slides

Container

Tissue transport kit (ARUP supply #47808)

Collection Instructions

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 8 unstained (3- to 5-micron thick sections), positively-charged slides.