Keppra (Levetiracetam)

Casandra

Casandra Test Code AR69910Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0098627CPT Code 80177

Keppra (Levetiracetam)

Also known as: KEPPRA

Clinical Use

Order Test

Use

Keppra (Levetiracetam) therapeutic drug monitoring is utilized to optimize drug therapy and monitor patient adherence. It is important for patients being treated for epilepsy or other conditions with Keppra to have their drug levels monitored to ensure efficacy and avoid potential toxicity. Renal function can affect the pharmacokinetics of levetiracetam, and adverse effects may include somnolence, weakness, headache, and vomiting.

Special Instructions

For optimal results, collect a predose (trough) sample at steady state concentration. Use of ARK Diagnostics reagents noted for cross-reactivity with brivaracetam. Patients switching from levetiracetam to brivaracetam or on both should use chromatographic methods instead for monitoring.

Limitations

The assay has known cross-reactivity with the drug brivaracetam (Briviact). It may report inaccurate results in patients transitioning to or using both levetiracetam and brivaracetam. For these cases, a validated chromatographic methodology should be used to distinguish and accurately determine drug concentrations. Toxicity thresholds are not well established.

Test Details

FDA Approved

New York Approved

Methodology

Immunoassay (EIA)

Biomarkers

Levetiracetam

Analyte

Concentration • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

30471-7

Result Turnaround Time

1 day

Specimen

Serum

Volume

1 mL

Minimum Volume

0.3 mL

Container

ARUP standard transport tube

Collection Instructions

Collect using a plain red, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin) tube. Separate serum or plasma from cells as soon as possible or within 2 hours of collection.