Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood

Casandra

Casandra Test Code MC54553Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID LAD1CPT Code 86356

Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood

Clinical Use

Use

Aiding in the diagnosis of leukocyte adhesion deficiency syndrome type 1, primarily in patients younger than 18 years. This test is useful for CD11a, CD11b, and CD18 phenotyping. Leukocyte adhesion deficiency syndrome type 1 is an autosomal recessive disorder caused by variants in the CD18 gene. It is characterized by recurrent infections, impaired wound healing, and persistent leukocytosis.

Special Instructions

Not provided.

Limitations

This test is typically not indicated in adults. Expression of CD18 alone is insufficient to exclude the diagnosis of leukocyte adhesion deficiency syndrome type 1; functional assays like neutrophil chemotaxis may be necessary if clinical suspicion remains high.

Test Details

New York Approved