Use

Quantitation of urinary metabolites of histamine, prostaglandin D2, and leukotriene E4 may provide significant clues for the diagnosis and management of symptomatic patients with both clonal and nonclonal mast cell activation syndromes. The presence of one or more elevated levels of these biomarkers in urine greatly narrows diagnostic possibilities, informs which metabolic pathways are involved, and enables personalized targeted treatment. The test is useful for evaluating patients at risk for mast cell activation syndrome (e.g., systemic mastocytosis, IgE‑mediated allergies, or aspirin‑exacerbated respiratory disease) using 24‑hour urine collections.